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Product Description
Caspase-12 Polyclonal Antibody | BS65665 | Bioworld
Host: Rabbit
Reactivity: Mouse,Rat,
Application: WB,
Application Range: WB=1:500-2000
Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Caspase-12 Polyclonal Antibody detects endogenous levels of Caspase-12 protein.
Molecular Weight: 46 kD
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene) ; Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.
Immunogen: KLH conjugated synthetic peptide derived from the middle of human Caspase-12
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway:
![Caspase-12 (NT) Antibody [Polyclonal] | PC-077](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/391321/569784/klogo__76714.1643661101__61470.1644059244.png?c=2 "Caspase-12 (NT) Antibody [Polyclonal] | PC-077")
