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Product Description
DTL polyclonal Antibody | BS71678 | Bioworld
Host: Rabbit
Reactivity: Mouse,Rat
Application: WB
Application Range: WB 1:500 - 1:2000
Background: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX (DTL) complex, also named CRL4 (CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21 (CIP1), FBXO18/FBH1 and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DTL polyclonal Antibody detects endogenous levels of DTL protein.
Molecular Weight: ~ 90 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CDT2; RAMP; DCAF2; L2DTL
Immunogen: Recombinant protein of human DTL
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
