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Product Description
APC mouse anti-human CD28 monoclonal Antibody | MB8503A | Bioworld
Host: Mouse
Reactivity: Human
Application: FC
Application Range: FC:5ul per test
Background: CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular) . CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs) . The CD86 expression on antigen presenting cells is constitutive (expression is independent of environmental factors) .CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.
Storage & Stability: Store at 4°C . Avoid freezed.
Specificity: This Antibody detects Extracellular domain of human CD28.
Molecular Weight: N/A
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: N/A
Immunogen: N/A
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway:
