Euro
USD
British Pound
NULL
Product Description
Bax Mouse monoclonal Antibody | MB9013 | Bioworld
Host: Mouse
Reactivity: Human,mouse
Application: WB ICC IHC FC
Application Range: WB: 1:500 ICC: 1:200 IHC: 1:200 FC: 1:50
Background: The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Bax and does not cross-react with related proteins.
Molecular Weight: ~ 21 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4
Immunogen: This Antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to N-terminal Bax.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway:
