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Product Description
c-Myb (Phospho-S11) polyclonal Antibody | BS94005 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC FC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: c-Myb (Phospho-S11) polyclonal Antibody detects endogenous levels of c-Myb protein only when phosphorylated at S11.
Molecular Weight: 72/75 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: MYB, C myb, C myb protein, Cmyb, MYB, Myb proto oncogene, V myb myeloblastosis viral oncogene homolog,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser11 of human V-Myb+C-Myb.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: ProA affinity purified
Pathway: PI3K AKT signaling,T cell receptor signaling,Adherens Junction signaling,MTOR signaling,
