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Product Description
CASP3 monoclonal Antibody | MB62703 | Bioworld
Host: Mouse
Reactivity: Human, Mouse, Rat
Application: WB
Application Range: WB 1:500
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Specificity: caspase 3
Molecular Weight: 31.4 kDa (Predicted)
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CPP32; CPP32B; SCA-1
Immunogen: Human recombinant protein fragment corresponding to amino acids 29-219 of human CASP3 (NP_116786) produced in E.coli.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway: N/A
