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Product Description
Catenin-β Mouse monoclonal Antibody | MB9005 | Bioworld
Host: Mouse
Reactivity: Human,mouse,rat
Application: WB ICC FC
Application Range: WB: 1:2000-1:5000 ICC: 1:100-1:200 FC: 1:50
Background: β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Catenin-β and does not cross-react with related proteins.
Molecular Weight: ~ 92 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Catenin β; Cateninβ; Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286
Immunogen: This Antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of beta-catenin.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway:
