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Product Description
Caveolin-1 Rabbit monoclonal Antibody | BS9878M | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC
Application Range: WB: 1:1000-1:5000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200
Background: Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis, and the compartmentalization of certain signaling molecules, including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated α and β, share a distinct but overlapping cellular distribution and differ by an amino-terminal 31 amino acid sequence which is absent from the β isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Caveolin-1 and does not cross-react with related proteins.
Molecular Weight: ~ 20 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Caveolin 1; Caveolin1; CAV1; CAV
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: T cell receptor signaling,Toll-like Receptor signaling,
