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Product Description
Cyclin D1 Rabbit monoclonal Antibody | BS9827M | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC/IF IHC IP
Application Range: WB: 1:1000-1:5000 IHC/ICC/IF: 1:50-1:200 IP: 1:50-1:200
Background: Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Cyclin D1 and does not cross-react with related proteins.
Molecular Weight: ~ 36 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene; CCND1; BCL1; PRAD1
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: Wntβ catenin signaling，Adherens Junction signaling,
