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Product Description
Cyclin E1 (Phospho-T77) polyclonal Antibody | BS94055 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC
Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Cyclins were first identified in invertebrates as proteins that oscillate dramatically through the cell cycle. These proteins have been well conserved through evolution and play a critical role in regulation of cell division. cyclin E, along with the three cyclin D proteins and cyclin C, has been shown to represent a putative G1 cyclin on the basis of its cyclic pattern of mRNA expression, with maximal levels being detected near the G1/S boundary. cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. The cyclin E/E2F complex is detected primarily during the G1 phase of the cell cycle and decreases as cells enter S phase. E2F is known to be a critical transcription factor for expression of several S phase specific proteins.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Cyclin E1 (Phospho-T77) polyclonal Antibody detects endogenous levels of Cyclin E1 protein only when phosphorylated at T77.
Molecular Weight: 48 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CCNE1, CCNE, Ccne1, CCNE1, cyclin E variant ex5del, cyclin E variant ex7del, Cyclin E1, Cyclin Es, Cyclin Et, CyclinE, G1/S specific cyclin E, G1/S-specific cyclin-E1,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr77 of human Cyclin E1.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: ProA affinity purified
Pathway:
