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Product Description
FosB polyclonal Antibody | BS90524 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP
Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: FosB polyclonal Antibody detects endogenous levels of FosB protein.
Molecular Weight: 48 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: FOSB, Activator protein 1, AP 1, DKFZp686C0818, FBJ murine osteosarcoma viral oncogene homolog B, fosB, FOSB, G0/G1 switch regulatory protein 3, G0S3, GOS 3, GOS B, GOS3, GOSB, MGC42291, Oncogene FOS B, Oncogene FOSB, Protein fos B, Protein fosB,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
