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Product Description
GART polyclonal Antibody | BS90562 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC IP
Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GART (GAR transformylase), also referred to as AIRS, GARS, PAIS, PGFT, PRGS or GARTF, is 1,010 amino acids in length and is a key folate-dependent trifunctional enzyme with phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase and AICAR (phosphoribosylaminoimidazole synthetase) activity required for de novo purine biosynthesis. Cancer cells require considerable amounts of purines to sustain their accelerated growth and GART is, therefore, a target for cancer chemotherapy. GART is highly conserved in vertebrates. Two isoforms of GART are expressed due to alternative splicing events.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: GART polyclonal Antibody detects endogenous levels of GART protein.
Molecular Weight: 107 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: GARS, AIRS, GART, 5'-phosphoribosylglycinamide transformylase, AIR synthase, AIRS, GAR transformylase, GARS, GART, GARTF, Glycinamide ribonucleotide synthetase, MGC47764, PAIS, PGFT, Phosphoribosyl-aminoimidazole synthetase, Phosphoribosylglycinamide formyltransferase, Phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthetase phosphoribosylaminoimidazole synthetase, Phosphoribosylglycinamide formyltransferase, EC 2.1.2.29, Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, Phosphoribosylglycinamide synthetase, PRGS, PUR2, Trifunctional purine biosynthetic protein adenosine 3,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: ESC Pluripotency and Differentiation Signaling Pathway,
