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Product Description
GEF H1 polyclonal Antibody | BS90570 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IF IHC FC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN) -derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: GEF H1 polyclonal Antibody detects endogenous levels of GEF H1 protein.
Molecular Weight: 111 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: GEF-H1, ARHGEF2, KIAA0651, LFP40, AA408978, ARHG2, ARHG2, ARHGEF 2, ARHGEF-2, ARHGEF2, GEF, GEF H1, GEF-H1, GEFH1, Guanine nucleotide exchange factor H1, KIAA0651, Lbcl1, Lfc, LFP40, MGC95068, Microtubule-regulated Rho-GEF, mKIAA0651, P40, Proliferating cell nucleolar antigen p40, Protein GEF-H1, Rho guanine nucleotide exchange factor 2, rho/rac guanine nucleotide exchange factor (GEF) 2, rho/rac guanine nucleotide exchange factor 2, rho/rac guanine nucleotide exchange factor,
Immunogen: Recombinant protein corresponding to C-terminal human GEF H1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
