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Product Description
GIT1 polyclonal Antibody | BS90574 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC FC
Application Range: WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:50-1:100
Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: GIT1 polyclonal Antibody detects endogenous levels of GIT1 protein.
Molecular Weight: 85 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ARF GAP GIT1, CAT-1, CAT1, GIT1, ARF GAP GIT1, ARF GTPase activating protein GIT1, ARF GTPase-activating protein GIT1, CAT 1, CAT-1, CaT1, Cool associated and tyrosine phosphorylated protein 1, Cool-associated and tyrosine-phosphorylated protein 1, G protein coupled receptor kinase interacting ArfGAP 1, G protein coupled receptor kinase interactor 1, G protein-coupled receptor kinase-interactor 1, GIT1, GIT1, GRK interacting protein 1, GRK-interacting protein 1,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
