Product Description
KDM5A polyclonal Antibody | BS90765 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IF FC
Application Range: WB:1:500 ICC:1:50-1:400 FC:1:50-1:100
Background: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: KDM5A polyclonal Antibody detects endogenous levels of KDM5A protein.
Molecular Weight: 192 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: RBBP-2, KDM5A, JARID1A, RBBP2, RBP2, Histone demethylase JARID1A, JARID1A, Jumonji/ARID domain containing protein 1A, Jumonji/ARID domain-containing protein 1A, Kdm5a, KDM5A, Lysine-specific demethylase 5A, RBBP-2, RBBP2, RBP2, Retinoblastoma binding protein 2, Retinoblastoma-binding protein 2 Antibody
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: