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Product Description
Matrin 3 polyclonal Antibody | BS90827 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IF IHC FC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: Matrin-3 is a nuclear matrix protein containing one matrin-type zinc finger and two RRM (RNA recognition motif) domains. Matrin-3 plays a role in transcription and may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the PSF-p54/NRB heteromer, Matrin-3 may play a role in the nuclear retention of defective RNAs. As the main substrate for PKA-mediated phosphorylation, Matrin-3 may serve as a rapid way of transferring information from synapses containing NMDA receptors to neuronal nuclei under physiological conditions. Also, the phosphorylation of Matrin-3 may contribute to neuronal death under pathological conditions. It is likely that Matrin-3 activity is regulated by calcium dependent interaction with CaM I and also by caspase induced cleavage.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Matrin 3 polyclonal Antibody detects endogenous levels of Matrin 3 protein.
Molecular Weight: 95 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: MATR3, ALS21, KIAA0723, Matr3, MATR3, Matrin-3, Matrin3, MPD2, VCPDM, Vocal cord and pharyngeal weakness with distal myopathy,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
