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Product Description
NM23 monoclonal Antibody | MB9388 | Bioworld
Host: Mouse
Reactivity: Human
Application: WB ICC IHC
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Specificity: NM23 monoclonal Antibody detects endogenous levels of NM23 protein.
Molecular Weight: 17/19 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: NDK A, NDP kinase A, GAAD, NME1, NDPKA, NM23, AWD, AWD, drosophila, homolog of, GAAD, Granzyme A activated DNase, Granzyme A-activated DNase, GZMA activated DNase, Metastasis inhibition factor NM23, NB, NBS, NDK A, NDKA, NDKA, NDP kinase A, NDPK-A, NDPKA, NM23, NM23 long variant, included, nm23-H1, NM23-M1, NM23H1B, included, NME/NM23 nucleoside diphosphate kinase 1, Nme1, NME1-NME2 spliced read-through transcript, included, Non-metastatic cells 1, protein (NM23A) expressed in, Nonmetastatic cells 1, protein expressed in, Nonmetastatic protein 23, Nonmetastatic protein 23, homolog 1, Nucleoside diphosphate kinase A, Tumor metastatic process-associated protein Antibody
Immunogen: Synthetic peptide within human NM23 aa 80-120.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein G purified.
Pathway:
