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Product Description
Noxa polyclonal Antibody | BS90958 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC FC
Application Range: WB:1:500 IHC:1:50-1:200 FC:1:50
Background: Members of the Bcl-2 family of proteins interact to regulate programmed cell death (apoptosis) under a broad range of physiological conditions. Bcl-2, Bcl-xL, and several related proteins inhibit apoptosis, whereas other members of the Bcl-2 family, such as Bax and Bak, enhance cell death. NOXA, a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. Murine cells constitutively express NOXA mRNA in small amounts in various organs; X-ray irradiation increases NOXA mRNA and protein expression levels. In human cells, NOXA, alternatively designated PMA-induced protein 1 or APR, displays high expression in the adult T cell leukemia cell line IKD, where it may function as an immediate-early-response gene. The NOXA protein selectively localizes to mitochondria.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Noxa polyclonal Antibody detects endogenous levels of Noxa protein.
Molecular Weight: 6 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PMA-induced protein 1, PMAIP1, NOXA, Adult T cell leukemia derived PMA responsive, APR, APR, ATL-derived, Immediate early response protein APR, Immediate-early-response protein APR, NOXA, Phorbol 12 myristate 13 acetate induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, PMA induced protein 1, PMA-induced protein 1, PMA-responsive gene, Pmaip1, Protein Noxa,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
![Noxa Antibody [Polyclonal] | PC-412](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/391178/569641/klogo__76714.1643661101__46214.1644059227.png?c=2 "Noxa Antibody [Polyclonal] | PC-412")
