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Product Description
p53 Mouse monoclonal Antibody | MB9015 | Bioworld
Host: Mouse
Reactivity: Human
Application: WB ICC IHC FC
Application Range: WB: 1:1000 IHC/ICC: 1:100-1:200 FC: 1:100-1:200
Background: p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of p53 and does not cross-react with related proteins.
Molecular Weight: ~ 53,43 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53
Immunogen: This Antibody is produced by immunizing mice with a recombinant protein corresponding to a region of p53.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway:
