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Product Description
PABPN1 polyclonal Antibody | BS91012 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC/IF IHC FC IP
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50
Background: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly (A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly (A) polymerase (PAPOLA) conferring processivity on the poly (A) tail elongation reaction and controls also the poly (A) tail length. Increases the affinity of poly (A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly (A) and to poly (G) with high affinity. May protect the poly (A) tail from degradation.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PABPN1 polyclonal Antibody detects endogenous levels of PABPN1 protein.
Molecular Weight: 49 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PABP-2, Poly (A) -binding protein 2, PABII, PABPN1, Nuclear poly (A) -binding protein 1, OPMD, PAB2, PABII, PABP 2, pABP-2, PABP2, PABP2, PABPII, Pabpn1, poly (A) binding protein nuclear 1, Poly (A) -binding protein 2, Poly (A) -binding protein II, PolyA binding protein II, Polyadenylate-binding nuclear protein 1, Polyadenylate-binding protein 2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
