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Product Description
Pax8 polyclonal Antibody | BS91026 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IHC FC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: The Pax family encodes transcription factors that function during embryogenesis and regulate the temporal and position-dependent differentiation of cells. Pax-8 is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. Pax-8 complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR) . Treatment of FRTL-5 cells with TGFβ1 decreases Pax-8 mRNA levels and Pax-8 DNA binding activity, which suppresses the expression of TG and the formation of thyrocytes. Patients who have autosomal dominant mutations of the Pax-8 gene develop thyroid dysgenesis. The Pax-8 gene produces six isoforms, A to F, that are generated by alternative splicing and differ in their carboxy-terminal regions. The Pax-8 isoforms display different DNA binding capacities and are thought to be functionally distinct. The gene which encodes Pax-8 maps to human chromosome 2q12-q14.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: Pax8 polyclonal Antibody detects endogenous levels of Pax8 protein.
Molecular Weight: 48 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PAX8, 2-cyclic phosphate 2-phosphohydrolase, 35-alpha calcimedin, Annexin A3, Annexin III, Annexin-3, ANX3, ANXA 3, Anxa3, ANXA3, Calcimedin 35 alpha, Inositol 1 2 cyclic phosphate 2 phosphohydrolase, Inositol 1, Lipocortin III, OTTHUMP00000160701, OTTHUMP00000219237, OTTHUMP00000219238, PAP III, PAP-III, Placental anticoagulant protein III,
Immunogen: Synthetic peptide within Human Pax8 aa 400-450.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified.
Pathway:
