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Product Description
Peroxiredoxin 3 polyclonal Antibody | BS91056 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IHC IP FC
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Peroxiredoxin 3 polyclonal Antibody detects endogenous levels of Peroxiredoxin 3 protein.
Molecular Weight: 24 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: AOP-1, Prx-III, PRDX3, AOP1, Antioxidant protein 1, AOP 1, AOP-1, AOP1, HBC189, MER5, MGC104387, MGC24293, mitochondrial, peroxiredoxin 3, Peroxiredoxin III, Peroxiredoxin-3, PRDX3, PRDX3, PRO1748, Protein MER5 homolog, PRX III, Prx-III, PRX3, SP 22, SP-22, SP22, Thioredoxin dependent peroxide reductase mitochondrial, Thioredoxin-dependent peroxide reductase,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
