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Product Description
SDHA polyclonal Antibody | BS91214 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat, Zebrafish
Application: WB ICC/IF IHC FC
Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: SDHA polyclonal Antibody detects endogenous levels of SDHA protein.
Molecular Weight: 68 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Fp, SDHA, CMD1GG, DHSA, Flavoprotein subunit of complex II, Fp, PGL5, SDH 2, SDH1, SDH2, SDHA, SDHF, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Succinate dehydrogenase complex flavoprotein subunit A, Succinate dehydrogenase complex flavoprotein subunit, Succinate dehydrogenase complex flavoprotein subunit precursor, Succinate dehydrogenase complex subunit A, Succinate dehydrogenase complex subunit A flavoprotein (Fp), Succinate dehydrogenase complex subunit A flavoprotein,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
