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Product Description
Stat1 α/β polyclonal Antibody | BS91284 | Bioworld
Host: Rabbit
Reactivity: Human, mouse
Application: WB ICC IHC FC
Application Range: WB:1:1,000 ICC:1:200 IHC:1:200, FC:1:100-1:200
Background: STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Stat1 α/β polyclonal Antibody detects endogenous levels of Stat1 α/β protein.
Molecular Weight: 87 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Stat-1, CANDF7, DKFZp686B04100, ISGF 3, ISGF3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal transducer and activator of transcription 1, Signal transducer and activator of transcription 1, 91kDa, Signal transducer and activator of transcription 1-alpha/beta, Stat1, STAT1, STAT91, Transcription factor ISGF-3 components p91/p84,
Immunogen: peptide
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified
Pathway:
