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Product Description
Tim3 monoclonal Antibody | MB9541 | Bioworld
Host: Mouse
Reactivity: Human
Application: WB IHC ICC FC
Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:100-1:200 FC:1:50-1:100
Background: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.
Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Specificity: Tim3 monoclonal Antibody detects endogenous levels of Tim3 protein.
Molecular Weight: 33/55 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: HAVcr-2, TIMD-3, TIM-3, HAVCR2, TIM3, TIMD3, CD366, FLJ14428, HAVcr-2, Havcr2, HAVR2, Hepatitis A virus cellular receptor 2, Kidney injury molecule 3, KIM 3, KIM3, T cell immunoglobulin and mucin domain containing 3, T cell immunoglobulin mucin 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim 3, TIM-3, TIM3, TIMD-3, TIMD3,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,T cell receptor signaling,
