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Product Description
Ubiquitin D polyclonal Antibody | BS91402 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC IHC
Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200
Background: FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for FAT10 conjugate formation. FAT10 is inducible by interferon-g and tumor necrosis factor a (TNF?) . The FAT10 protein interacts with MAD2, a component of the spindle checkpoint, and plays a role in antigen presentation, cytokine response, apoptosis and mitosis. It may also regulate cell growth during dendritic cell or B cell activation and development. FAT10 mRNA is expressed mainly in some dendritic cells and lymphoblastoid lines and in other specific cells subsequent to interferon-g induction. The human FAT10 gene, designated UBD, maps to chromosome 6p21.3 and is overexpressed in the tumors of various epithelial cancers.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Ubiquitin D polyclonal Antibody detects endogenous levels of Ubiquitin D protein.
Molecular Weight: 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: UBD, Diubiquitin, FAT10, GABBR1, UBD 3, Ubd, UBD, Ubiquitin D, Ubiquitin like protein FAT10, Ubiquitin-like protein FAT10,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: PI3K AKT signaling,MTOR signaling,
