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Product Description
Wnt5a polyclonal Antibody | BS91454 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB ICC IHC FC
Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 ICC:1:50 FC:1:50-1:100
Background: The Wnt genes belong to a family of protooncogenes with at least 13 known members that are expressed in species ranging from Drosophila to man. The name Wnt denotes the relationship of this family to the Drosophila segment polarity gene "wingless" and to its vertebrate ortholog, Int1, a mouse protooncogene. Transcription of Wnt family genes appears to be developmentally regulated in a precise temporal and spatial manner. The Wnt genes encode cysteine-rich putative glycoproteins, which have features typical of secreted growth factors. Northern blot analysis detects expression of Wnt-5a in brain, lung, and heart. At least five distinct Wnt-5a transcripts are observed, which are due to transcript variability 5-prime to the initiation methionine. In situ hybridization detects a complex spatial and temporal pattern of Wnt-5a in the mouse, including expression in the developing central nervous system, limbs, facial processes, and the posterior region of the fetus. Human frizzled-5 is the receptor for the Wnt-5a ligand. It is suggested that Wnt-5a augments primitive hematopoietic development in vivo and represents an in vivo regulator of hematopoietic stem cell function in the human.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Wnt5a polyclonal Antibody detects endogenous levels of Wnt5a protein.
Molecular Weight: 42 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: WNT5A, hWNT 5A, hWNT5A, Protein Wnt 5a, Protein Wnt-5a, Protein Wnt5a, Wingless type MMTV integration site family member 5A, Wnt 5a, WNT 5A protein, WNT 5A protein precursor, WNT5A, WNT5A protein precursor, WNT5A,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
