Euro
USD
British Pound
NULL
Product Description
ATP citrate lyase polyclonal Antibody | BS90107 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IHC FC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100
Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, in animals serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated by insulin. In plants, ATP citrate lyase generates the acetyl-CoA for cytosolically-synthesized metabolites. (Acetyl-CoA is not transported across subcellular membranes of plants.) These include: elongated fatty acids (used in seed oils, membrane phospholipids, the ceramide moiety of sphingolipids, cuticle, cutin, and suberin) ; flavonoids; malonic acid; acetylated phenolics, alkaloids, isoprenoids, anthocyanins, and sugars; and, mevalonate-derived isoprenoids (e.g., sesquiterpenes, sterols, brassinosteroids) ; malonyl and acyl-derivatives (d-amino acids, malonylated flavonoids, acylated, prenylated and malonated proteins) . De novo fatty acid biosynthesis in plants is plastidic, thus ATP citrate lyase is not important for this pathway.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: ATP citrate lyase polyclonal Antibody detects endogenous levels of ATP citrate lyase protein.
Molecular Weight: 122 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ACL, ACLY, ACL, Acly, ACLY, ATP citrate (pro-S) lyase, ATP citrate lyase, ATP citrate synthase, ATP-citrate (pro-S-) -lyase, ATP-citrate synthase, ATPcitrate synthase, ATPCL, Citrate cleavage enzyme, CLATP, OTTHUMP00000164773,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein affinity purified.
Pathway:
