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Product Description
Clock (E270) polyclonal Antibody | BS1873 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Clock, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Clock (E270) polyclonal Antibody detects endogenous levels of Clock protein.
Molecular Weight: ~ 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Circadian locomoter output cycles protein kaput; hCLOCK; Class E basic helix-loop-helix protein 8; bHLHe8; CLOCK; BHLHE8; KIAA0334
Immunogen: Synthetic peptide, corresponding to amino acids 241-290 of Human Clock.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
