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Product Description
MKP-2 (Y108) polyclonal Antibody | BS2302 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: IHC
Application Range: IHC: 1:50~1:200
Background: Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP- 4. Human MKP-2 maps to chromosome 8p12-p11 and encodes a 394 amino acid, 43 kDa protein that specifically inactivates ERK1, ERK2 and JNK.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MKP-2 (Y108) polyclonal Antibody detects endogenous levels of MKP-2 protein.
Molecular Weight: ~ 44 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2; DUSP4; MKP2; VH2
Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human MKP-2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
