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Product Description
NPM1 monoclonal Antibody | MB0086 | Bioworld
Host: Mouse
Reactivity: Human,Mouse
Application: WB ICC
Application Range: WB: 1:1000 ICC: 1:100~200
Background: Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of NPM1 and does not cross-react with related proteins
Molecular Weight: Predicted band size:33KDa Observed band size:38KDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; NPM1; NPM
Immunogen: Recombinant full length Human NPM1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
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