Euro
USD
British Pound
NULL
Product Description
p53 (Phospho-T55) polyclonal Antibody | BS94087 | Bioworld
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB:1:1,000-1:2,000
Background: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: p53 (Phospho-T55) polyclonal Antibody detects endogenous levels of p53 protein only when phosphorylated at T55.
Molecular Weight: 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: TP53, Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, FLJ92943, LFS1, Mutant tumor protein 53, p53, p53 tumor suppressor, P53, Phosphoprotein p53, Tp53, Transformation related protein 53, TRP53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr55 of human p53
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: ProA affinity purified
Pathway:
![p53 Antibody (T55) [APR05729G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/867618/1159685/logo__92149.1659788186__33456.1659863702.png?c=2 "p53 Antibody (T55) [APR05729G]"){kind=logo}
