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Product Description
PTEN (Phospho-S380) polyclonal Antibody | BS94022 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC
Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500
Background: As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PTEN (Phospho-S380) polyclonal Antibody detects endogenous levels of PTEN protein only when phosphorylated at S380.
Molecular Weight: 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PTEN, 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, Phosphatase and tensin like protein, Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Pten, PTEN, PTEN1, TEP1,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser380 of human PTEN.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: ProA affinity purified
Pathway: MTOR signaling,
