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Product Description
SFTPA1 polyclonal Antibody | BS60561 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Pulmonary surfactant is primarily responsible for lowering the surface tension at the air-liquid interface in the alveoli, a process that is essential for normal respiration. Pulmonary surfactant is a mixture of phospholipids and proteins, including four distinct surfactant-associated proteins (SPs), SP-A, SP-B, SP-C, SP-D. SP-B and SP-C are predominantly hydrophobic proteins that associate with lipids to promote the absorption of surfactant phospholipids and to reduce the surface tension in the alveoli. SP-A and SP-D are large multimeric proteins belonging to the family of calcium-dependent lectins, designated collectins, which contribute to the innate immune system. Both SP-A and SP-D have been shown to protect against microbial challenge through binding to the lipid components of the bacterial cell wall and facilitating the rapid removal of microbials. In humans, there are four SFTPA genes localized on chromosome 10. Research indicates that the SFTPA genes are differentially regulated by glucocorticoids, insulin, and cAMP. Expression of two highly similar SP-A proteins, SP-A1 and SP-A2 has been confirmed.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SFTPA1 polyclonal Antibody detects endogenous levels of SFTPA1 protein.
Molecular Weight: ~ 26 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4; SFTPA1; COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B
Immunogen: A synthetic peptide corresponding to residues in Human SFTPA1
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
