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Product Description
SLC4A7 polyclonal Antibody | BS60770 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: SLC4A7 (solute carrier family 4 member 7), also known as sodium bicarbonate cotransporter 3, is a 1,214 amino acid multi-pass membrane protein that mediates the movement of sodium and bicarbonate across the cell membrane. Studies in mice have shown that hydrogen ion disposal mediated by SLC4A7 is essential for auditory and visual systems, therefore, defects in the gene encoding SLC4A7 may result in the human manifestation of Usher syndrome, a leading cause of deafblindness. With highest expression in spleen and testis, SLC4A7 is also expressed in a variety of other tissues, including brain, skeletal muscle and heart. Due to its critical role in intracellular pH regulation, SLC4A7 is notably affected by hypoxic states during which protein levels are decreased, presumably for reduction of energy consumption. There are five isoforms of SLC4A7 that exist as a result of alternative splicing events.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SLC4A7 polyclonal Antibody detects endogenous levels of SLC4A7 protein.
Molecular Weight: ~ 136 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Sodium bicarbonate cotransporter 3; Electroneutral Na/HCO (3) cotransporter; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7; SLC4A7; BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6
Immunogen: A synthetic peptide corresponding to residues in Human SLC4A7.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
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