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Product Description
Catenin-δ1 (phospho-Y228) polyclonal Antibody | BS4381 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function. Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion. Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion. Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins. Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Catenin-δ1 (phospho-Y228) polyclonal Antibody detects endogenous levels of Catenin-δ1 protein only when phosphorylated at Tyr228.
Molecular Weight: ~ 95, 100 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120 (ctn) ; p120 (cas) ; CTNND1
Immunogen: Synthetic phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of Tyrosine 228
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
