Euro
USD
British Pound
NULL
Product Description
Cdk5 (phospho-Y15) polyclonal Antibody | BS4596 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks) . Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk5 is thought to be involved in the G1/S transition of the cell cycle and is highly expressed in mature neurons. Activity of Cdk5 increases significantly during neuronal differentiation. Cdk5 has been postulated to be a neurofilament or Tau protein kinase, based on its ability to phosphorylate these proteins in vitro.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Cdk5 (phospho-Y15) polyclonal Antibody detects endogenous levels of Cdk5 protein only when phosphorylated at Tyr15.
Molecular Weight: ~ 33 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclin-dependent-like kinase 5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit; CDK5; CDKN5
Immunogen: Synthetic phosphopeptide derived from human Cdk5 around the phosphorylation site of Tyrosine15.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Phosphoinosotode Signaling,PI3K AKT signaling,Hypoxia Signaling,Warburg Effect,Insulin &Glucose Signaling,Glutamine Metabolism,MTOR signaling,ErbB HER Signaling,
