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Product Description
CKR-5 (phospho-S349) polyclonal Antibody | BS4032 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR) . CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M) -tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: p-CKR-5 (S349) polyclonal Antibody detects endogenous levels of CKR-5 protein only when phosphorylated at Ser349.
Molecular Weight: ~ 41 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CD195; CCR5; CMKBR5
Immunogen: Synthetic phosphopeptide derived from human CKR-5 around the phosphorylation site of Serine 349.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,
