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Product Description
HRSP12 polyclonal Antibody | BS70623 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB 1:500 - 1:2000
Background: HRSP12 (heat-responsive protein 12), also known as PSP, P14.5 or UK114, is a 137 amino acid protein that belongs to the UPF0076 (UK114) family and is expressed primarily in liver and kidney. Localized to the cytoplasm in highly differentiated cells and to the nucleus in less differentiated cells, HRSP12 functions as an endoribonuclease that inhibits translation by cleaving mRNA. Specifically, HRSP12 cleaves phosphodiester bonds in single-stranded mRNA, thereby breaking the mRNA and preventing protein synthesis. HRSP12 exists as a homotrimer and may be a tumor antigen involved in malignant neoplasms. This suggests a possible role in carcinogenesis.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: HRSP12 polyclonal Antibody detects endogenous levels of HRSP12 protein.
Molecular Weight: ~ 14.5 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Ribonuclease UK114; p14.5; Heat-responsive protein 12; UK114 antigen homolog; PSP
Immunogen: Recombinant protein of human HRSP12.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
