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Product Description
KDM7A polyclonal Antibody | BS71141 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB 1:500 - 1:2000
Background: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: KDM7A polyclonal Antibody detects endogenous levels of KDM7A protein.
Molecular Weight: ~ 107 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Lysine-specific demethylase 7A; JmjC domain-containing histone demethylation protein 1D; Lysine-specific demethylase 7; JHDM1D; KDM7; KIAA1718
Immunogen: Recombinant protein of human KDM7A.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
