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Product Description
NRL polyclonal Antibody | BS5829 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Nrl (neural retina leucine zipper) is a member of the Maf family of transcription factors, which characteristically contain a highly conserved basic leucine zipper (bZIP) -DNA binding motif. Both Nrl and c-Maf preferentially bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The Maf-Nrl subfamily regulates the expression of cell type-specific genes in tissues of the hematopoietic system, cerebellum and developing hindbrain. Maf and Nrl proteins bind an extended AP-1-like sequence and can form heterodimers with Fos and Jun transcription factors. In retinal cells and photoreceptor cells, Nrl promotes the expression of rhodopsin through binding to the Nrl response element present in the rhodopsin promoter. Nrl is expressed throughout the developing central and peripheral nervous system during neuronal differentiation, and its expression is restricted to neocortex, brainstem and retinal neurons during adulthood.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: NRL polyclonal Antibody detects endogenous levels of NRL protein.
Molecular Weight: ~ 30 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Neural retina-specific leucine zipper protein; D14S46E
Immunogen: Synthetic peptide, corresponding to amino acids 42-87 of Human NRL.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
