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Product Description
OXSR1 polyclonal Antibody | BS5837 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Oxidative stress-responsive 1 protein (OXSR1), a protein of 527 amino acids, belongs to the STE20 subfamily. OXSR1 is one of two human homologs of Fray, a serine/threonine kinase expressed in Drosophila. OXSR1 binds to and phosphorylates p21-activated protein kinase PAK1 and regulates downstream kinases in response to environmental stress. Endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 may also play a role in regulating the actin cytoskeleton. The chloride channel proteins SLC12A1, SLC12A2, and SLC12A6 isoform 2 interact with OXSR1, but SLC12A4 and SLC12A7 do not. The WNK1 and WNK4 protein kinases activate OXSR1 by phosphorlating its T-loop. The OXSR1 protein is widely expressed in mammalian tissues.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: OXSR1 polyclonal Antibody detects endogenous levels of OXSR1 protein.
Molecular Weight: ~ 58 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Serine/threonine-protein kinase OSR1; Oxidative stress-responsive 1 protein; KIAA1101; OSR1
Immunogen: Synthetic peptide, corresponding to amino acids 312-357 of Human OXSR1.
Conjugate: N/A
Modification: N/A
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: N/A
