Product Description
Troponin I3 (phospho-T142) polyclonal Antibody | BS4282 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC) . Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Troponin I3 (phospho-T142) polyclonal Antibody detects endogenous levels of Troponin I3 protein only when phosphorylated at Thr142.
Molecular Weight: ~ 28 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Troponin I, cardiac muscle; Cardiac troponin I; TNNI3; TNNC1
Immunogen: Synthetic phosphopeptide derived from human Troponin I3 around the phosphorylation site of Thr142.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Phosphoinosotode Signaling,PI3K AKT signaling,Protein Kinase C Signaling,Warburg Effect,T cell receptor signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,Adherens Junction signaling,Mitochondrial Control of Apoptosis,MTOR signaling,ErbB HER Signaling,