Product Description
CLC-4 (E254) polyclonal Antibody | BS3103 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IF
Application Range: WB: 1:500~1:1000 IF: 1:50~1:200
Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CLC-4 (E254) polyclonal Antibody detects endogenous levels of CLC-4 protein.
Molecular Weight: ~ 85 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: H (+) /Cl (-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4; CLCN4; CLC 4; CLC4
Immunogen: Synthetic peptide, corresponding to amino acids 240-280 of Human CLC-4.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: