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Product Description
Histone H2A.X (phospho-S139) monoclonal Antibody | MB0175 | Bioworld
Host: Mouse
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB: 1:1000~2000 IF: 1:200~500
Background: H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Histone H2A.X protein only when phosphorylated at Ser139, and does not cross-react with related proteins.
Molecular Weight: Predicted band size:15KDa Observed band size:15KDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX; γ-H2AX; γH2AX; ganunaH2AX; γ-H2A.X; γH2A.X; ganunaH2A.X
Immunogen: Synthetic phosphopeptide derived from human Histone H2A.X around the phosphorylation site of Serine 139.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Cell Cycle Control G1 S Checkpoint,
