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Product Description
IL17F polyclonal Antibody | BS8257 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: The proinflammatory cytokine Interleukin 17 (IL-17) is produced by activated T cells to elicit potent cellular responses. IL-17 is secreted as a disulfide-linked homodimeric glycoprotein. A human IL-17 homolog IL-17E is a ligand for EV127/IL-17BR, which is also known as IL-17 receptor homolog 1. IL-17E mRNA is detected at very low levels in several peripheral tissues. IL-17E induces the activation of NFκB and stimulates the production of the proinflammatory chemokine IL-8. In addition, IL-17E has catabolic activity on human articular cartilage. IL-17E is a unique pleiotropic cytokine that may be an important mediator of inflammatory and immune responses. Another homolog of IL-17, IL-17F, is a secreted cytokine expressed only in activated CD4+ T cells and activated monocytes. IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and regulates cartilage matrix turnover.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IL17F polyclonal Antibody detects endogenous levels of IL17F protein.
Molecular Weight: ~ 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Interleukin-17F; IL-17F; Cytokine ML-1; IL17F
Immunogen: Recombinant full length Human IL17F.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
