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Product Description
MSR1 polyclonal Antibody | BS6671 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB 1:500 - 1:2000 IF 1:10 - 1:100
Background: The macrophage class A scavenger receptor (SR-A) mediates the uptake of modified low density lipoprotein (LDL) . The gene encoding human SR-A maps to chromosome 8 and gives rise to two alternatively spliced isoforms, type I and II (SR-AI and SR-AII), which were originally cloned from the phorbol ester-treated human monocytic cell line THP-1. Both isoforms contain six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V) and a type-specific C-terminal (VI) ) . Domain IV is essential for the trimerization of SR-A, whereas domain V is essential for the wide range of ligand recognition. SR-A is expressed in liver, placenta and brain. Both SR-AI and SR-AII mediate the uptake of LDLs in atherosclerotic lesions. A third isoform,
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MSR1 polyclonal Antibody detects endogenous levels of MSR1 protein.
Molecular Weight: ~ 63 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD204; MSR1; SCARA1
Immunogen: Recombinant full length Human MSR1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
