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Product Description
TRAF6 polyclonal Antibody | BS6076 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IκB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFκB signaling pathway.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TRAF6 polyclonal Antibody detects endogenous levels of TRAF6 protein.
Molecular Weight: ~ 58 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: E3 ubiquitin-protein ligase TRAF6; Interleukin 1 signal transducer; Interleukin-1 signal transducer; MGC 3310; MGC 3310; MGC:3310; MGC3310; OTTHUMP00000232772; OTTHUMP00000232773; RING finger protein 85; RNF 85; RNF85; RNF85; TNF receptor associated factor 6; TNF receptor associated factor 6; TNF receptor-associated factor 6; TRAF 6; Traf6; TRAF6;
Immunogen: Recombinant full length Human TRAF6.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
