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Product Description
WFS1 polyclonal Antibody | BS6764 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB,IF
Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200
Background: The Wolframin gene encodes a protein found in endoplasmic reticulum membrane of several tissues including brain, pancreas, lung and placenta. Loss-of-function mutations in both alleles result in Wolfram syndrome (also known as DIDMOAD, an autosomal recessive disorder that causes juvenile diabetes mellitus, diabetes insipidus, optic atrophy and a number of neurological symptoms including deafness, ataxia and peripheral neuropathy. A large number and variety of mutations in this gene, particularly in exon 8, can be associated with Wolfram syndrome. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: WFS1 polyclonal Antibody detects endogenous levels of WFS1 protein.
Molecular Weight: ~ 110 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Wolframin
Immunogen: Recombinant full length Human WFS1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
