Euro
USD
British Pound
NULL
Product Description
GALNT3 polyclonal Antibody | BS8280 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the golgi apparatus. GalNAc-T3, also known as GALNT3, HHS or HFTC, is a 633 amino acid single-pass type II membrane protein that localizes to the golgi and contains one ricin B-type lectin domain. Expressed at high levels in kidney, testis, skin and pancreas, GalNAc-T3 uses manganese and calcium as cofactors to catalyze the first reaction in O-linked oligosaccharide biosynthesis, namely the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on a target protein. Defects in the gene encoding GalNAc-T3 are the cause of hyperphosphatemic familial tumoral calcinosis (HFTC) and hyperostosis-hyperphosphatemia syndrome (HHS) . GalNAc-T3 is overexpressed in carcinoma tissue, suggesting a role in tumor development and metastasis.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GALNT3 polyclonal Antibody detects endogenous levels of GALNT3 protein.
Molecular Weight: ~ 73 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Polypeptide N-acetylgalactosaminyltransferase 3; Polypeptide GalNAc transferase 3; GalNAc-T3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; GALNT3
Immunogen: Recombinant full length Human GALNT3.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway:
![GALNT3 Antibody (Center) [APR32671G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/872916/1164983/logo__92149.1659788186__43446.1659868851.png?c=2 "GALNT3 Antibody (Center) [APR32671G]"){kind=logo}